5-Amino-1MQ (10mg vials)

Description

5-Amino-1MQ (5-amino-1-methylquinolinium) is a non-peptide research chemical built around a methylquinolinium scaffold. It is widely referenced in cellular biochemistry literature as a small-molecule tool compound for probing the enzyme nicotinamide N-methyltransferase (NNMT).

NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide. By acting on this enzyme, 5-Amino-1MQ is used in vitro to interrogate how NNMT activity intersects with nicotinamide turnover, cellular methyl-donor balance, and NAD+ salvage chemistry. Its relatively compact structure and reported selectivity have made it a common reference point in structure-activity and enzyme-kinetics work.

This compound is of interest to laboratories examining metabolic regulation at the cellular level. General areas where it appears in the research record include:

• NNMT enzyme-inhibition assays and inhibitor characterization
• Nicotinamide and methyl-nicotinamide metabolism in cultured cells
• NAD+ salvage-pathway and methylation-pathway biochemistry
• Adipocyte and other cell-line models studying NNMT expression
• Structure-activity and small-molecule inhibitor screening

Each unit contains 10mg of 5-Amino-1MQ as a lyophilized powder, sealed in a glass vial. Material is verified by HPLC and mass spectrometry, and a Certificate of Analysis (COA) documenting identity and purity is available on request. Note that the reported molecular weight corresponds to the cation; confirm the exact salt form against the COA. Store sealed and protected from light and moisture, and reconstitute with an appropriate solvent following your laboratory’s handling protocols.

Research Use Only: This material is supplied strictly for laboratory research. Not for human or animal consumption. It is not a drug, food, supplement, or cosmetic and has not been approved by the FDA.