CJC-1295 no DAC (10mg vials)

Description

CJC-1295 no DAC, also referred to in peptide literature as Modified GRF (1-29), is a short synthetic analog of growth hormone-releasing hormone (GHRH). It carries several amino acid substitutions relative to the native GHRH(1-29) sequence that improve resistance to enzymatic breakdown while preserving the molecule’s affinity for the GHRH receptor. Unlike the DAC-bearing version of this peptide, this variant omits the Drug Affinity Complex, so it does not covalently attach to serum albumin and exhibits a comparatively short profile of activity in experimental settings.

Because it lacks the albumin-binding modification, CJC-1295 no DAC is frequently used as a reference compound in studies that compare modified GHRH analogs and examine how individual structural changes influence receptor engagement and peptide stability. Investigators commonly pair it with secretagogue peptides in cellular models to probe GHRH-axis signaling.

Each unit contains 10mg of lyophilized peptide sealed in a glass vial. Material is verified for identity and purity by HPLC and mass spectrometry, with a Certificate of Analysis available for each batch. Store vials sealed and protected from light; lyophilized peptide is best held frozen for long-term stability, and reconstituted solution should be kept refrigerated and used within a short window.

General areas of laboratory research interest include:

• GHRH receptor pharmacology and binding kinetics in pituitary cell models
• Structure-activity studies comparing modified and unmodified GHRH sequences
• Downstream signal transduction following GHRH receptor activation
• Peptide stability and enzymatic resistance of substituted GHRH analogs
• Comparative work alongside related secretagogue and GHRH-family peptides

Research Use Only: This material is supplied strictly for laboratory research. Not for human or animal consumption. It is not a drug, food, supplement, or cosmetic and has not been approved by the FDA.