MOTS-c (10mg vials)

Description

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a short peptide encoded within the mitochondrial genome, specifically within the 12S ribosomal RNA region. First characterized in the mid-2010s, it belongs to a small but growing group of signaling molecules known as mitochondrial-derived peptides (MDPs), a family that also includes humanin and the SHLP series.

At the cellular level, MOTS-c is of interest because it appears to act as a messenger between the mitochondria and the rest of the cell. Research has examined its association with AMP-activated protein kinase (AMPK) signaling, a central node in how cells sense and respond to energy availability. This positions MOTS-c as a useful tool compound for studies of mitochondrial-to-nuclear communication and metabolic pathway regulation.

Because it was among the earliest mitochondrial-derived peptides to be described, MOTS-c is frequently used as a reference molecule in foundational work on this peptide class. Investigators have explored its behavior in a range of in vitro and model systems.

• Mitochondrial-derived peptide biology and the broader MDP family
• Mitochondrial-to-nuclear signaling and retrograde communication
• AMPK-linked energy sensing and metabolic pathway research
• Cellular aging and metabolic-state model systems
• Skeletal muscle and exercise-stress responses in cell and model studies

Each lot from Bolt Peptide is provided as a lyophilized powder in a sealed glass vial and is accompanied by a Certificate of Analysis. Identity and purity are confirmed by HPLC and mass spectrometry. For best stability, store sealed vials cold and protected from light, and reconstitute only with appropriate handling in a controlled laboratory setting.

Research Use Only: This material is supplied strictly for laboratory research. Not for human or animal consumption. It is not a drug, food, supplement, or cosmetic and has not been approved by the FDA.