MOTS-c (40mg vials)

Description

MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA-c) is a short peptide of 16 amino acids that originates from a small open reading frame inside the mitochondrial 12S ribosomal RNA gene. First characterized in 2015, it belongs to a growing family of mitochondrial-derived peptides (MDPs) that also includes humanin and the SHLP series. With an approximate molecular weight near 2.2 kDa, it has become a frequent reference point in studies of how mitochondria participate in cellular signaling beyond classical energy production.

Research interest in MOTS-c centers on its proposed involvement in retrograde signaling, the process by which mitochondria communicate metabolic status to the nucleus. Investigators frequently examine its reported associations with AMP-activated protein kinase (AMPK) signaling and downstream metabolic regulatory networks, making it a useful tool compound for in vitro and model-system work on cellular energy balance.

This Bolt Peptide listing supplies MOTS-c as a single 40mg quantity of lyophilized powder in a sealed glass vial, intended for reconstitution in an appropriate solvent under laboratory conditions.

• Mitochondrial-derived peptide biology and the broader MDP class
• Mitochondrial-to-nuclear (retrograde) signaling pathways
• AMPK-linked cellular metabolism and energy-sensing research
• Metabolic state and cellular aging model investigations
• Skeletal muscle and exercise-stress responses in cell and model systems

Each lot is characterized for identity and purity by HPLC and mass spectrometry, with a certificate of analysis available on request. Store lyophilized material cold and protected from light, and handle using standard laboratory practices for research peptides.

Research Use Only: This material is supplied strictly for laboratory research. Not for human or animal consumption. It is not a drug, food, supplement, or cosmetic and has not been approved by the FDA.