Description
SS-31 is a small synthetic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂, where Dmt denotes the non-standard residue 2′,6′-dimethyltyrosine. Its alternating cationic and aromatic character is the structural feature most often discussed in the context of how the molecule partitions toward the inner mitochondrial membrane in cell-based experimental systems.
In the research literature, SS-31 is examined chiefly for its reported affinity for cardiolipin, a phospholipid concentrated in the inner mitochondrial membrane. This association makes the peptide a frequently used probe in investigations of mitochondrial membrane organization, electron transport chain activity, and the broader question of compartment-selective peptide delivery to subcellular targets.
Bolt Peptide offers SS-31 as a lyophilized powder for use in controlled in vitro and laboratory settings by qualified investigators. Reported uses in the scientific literature are described here for background only and do not constitute any claim regarding outcomes.
- Mitochondrial membrane and cardiolipin interaction studies
- Electron transport chain and bioenergetics research
- Peptide chemistry and structure-targeting investigations
- Methods development for subcellular-selective delivery
Each vial contains 10mg of SS-31 (molecular weight approximately 640 Da). Purity is assessed by high-performance liquid chromatography (HPLC) and confirmed by mass spectrometry, and a Certificate of Analysis (COA) is available for each lot. Store lyophilized material cold and protected from light, reconstitute with an appropriate solvent, and handle using standard laboratory practice.
Research Use Only: This material is supplied strictly for laboratory research. Not for human or animal consumption. It is not a drug, food, supplement, or cosmetic and has not been approved by the FDA.


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