TB-500 (TB4, 10mg vials)

Description

TB-500 is a short synthetic peptide modeled on the central, actin-binding portion of Thymosin Beta-4 (Tβ4), a 43-residue protein expressed widely across mammalian cells. Rather than reproducing the full parent protein, this fragment isolates the conserved sequence most closely associated with Tβ4’s interaction with G-actin, making it a convenient tool for studying that activity in isolation.

At the molecular level, the peptide is of interest for its capacity to bind and sequester monomeric actin, a function tied to the regulation of cytoskeletal assembly and turnover. Because the parent protein participates in a broad range of cellular processes, the fragment is frequently used as a reference compound when researchers want to probe actin-related dynamics without the complexity of the intact 43-amino-acid molecule.

Investigators have examined Tβ4 and its derived fragments in a number of preclinical and in vitro contexts. The areas below summarize general directions reported in the scientific literature and are provided for research orientation only.

• Actin sequestration and cytoskeletal organization in cell-based assays
• Cell migration and motility studies using endothelial, epithelial, and fibroblast models
• Signaling research relating to vascular development and angiogenesis pathways
• Cellular inflammatory response and cytokine signaling investigations
• Comparative analytical work contrasting the fragment with full-length Thymosin Beta-4

Each vial from Bolt Peptide contains 10mg of lyophilized TB-500 sealed under conditions suited to peptide stability. Identity and purity are assessed by HPLC and mass spectrometry, with a certificate of analysis available for each lot. For best results, store vials cold, protect from light and moisture, and reconstitute with an appropriate sterile diluent immediately before use in your protocol.

Research Use Only: This material is supplied strictly for laboratory research. Not for human or animal consumption. It is not a drug, food, supplement, or cosmetic and has not been approved by the FDA.