What Is Ipamorelin? A Research Overview

Ipamorelin is a synthetic pentapeptide characterized in research as a selective growth hormone secretagogue (GHS) and ghrelin-receptor agonist. It is studied in preclinical endocrinology research as a model compound for growth-hormone (GH) release. Supplied strictly for laboratory research use only — not for human or veterinary use.

Quick facts

• Class: synthetic pentapeptide, growth hormone secretagogue
• CAS: 170851-70-4
• Research focus: selective GH release via the ghrelin/GHS receptor
• Form: lyophilized powder for laboratory research use only

What is Ipamorelin?

Ipamorelin is one of the most selective growth hormone secretagogues characterized in the literature. In preclinical models it stimulates GH release from the pituitary while reportedly having little effect on cortisol or prolactin, and it tends to preserve the natural pulsatile pattern of GH release.

What does the research show?

Evidence is preclinical. In a foundational rat study, Ipamorelin produced dose-dependent GH release and induced longitudinal bone growth, supporting its use as a model GH secretagogue in animal research. Its selectivity — releasing GH without strongly activating other pituitary hormones — is a frequent focus of comparative secretagogue research.

Mechanisms studied in the lab

• Ghrelin/GHS-receptor agonism — binds the growth-hormone-secretagogue receptor
• Selective GH release — minimal reported impact on cortisol and prolactin in models
• Pulsatile signaling — preserves the natural rhythm of GH secretion

Research status and safety

Findings are limited to laboratory and animal research. Ipamorelin is not approved for human use and is supplied for in-vitro research only.

Handling

Ipamorelin is supplied as a lyophilized research material. Qualified laboratory personnel must establish storage, solvent compatibility, material handling, and final concentration under documented institutional SOPs. See Ipamorelin — product details, review the analytical concentration reference, or browse the research peptide catalog.

FAQ

Is Ipamorelin the same as CJC-1295? No — they are distinct compounds often studied together; CJC-1295 is a GHRH analogue, while Ipamorelin is a ghrelin-receptor secretagogue.

Is Ipamorelin for human use? No. Research use only; not FDA-approved.

References

1. Svensson J, et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. 1999. PubMed
2. Ipamorelin — research peptide profile. Peptpedia. Reference

For research use only. Not for human or veterinary use. Statements have not been evaluated by the FDA.