VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide of the secretin/glucagon peptide superfamily that signals through the class B G-protein-coupled receptors VPAC1 and VPAC2. It is studied in neuroendocrine, vascular, and immunomodulation research. This article is educational only. VIP is discussed here strictly as a research compound; it is for research use only (RUO) and […]
Author: Bolt Peptide
What Is FOXO4-DRI? A Senolytic Research Peptide Explained
FOXO4-DRI is a synthetic D-retro-inverso (DRI) peptide designed to disrupt the FOXO4–p53 protein interaction inside senescent cells, and it is studied as a senolytic research tool in cellular-senescence biology. It is investigated for its ability to selectively trigger programmed cell death in senescent (“aged”) cells while sparing healthy ones in laboratory and animal models. This […]
What Is Adipotide (FTPP / Prohibitin-TP01)? A Research Overview
Adipotide, also called FTPP or Prohibitin-TP01, is an experimental peptidomimetic studied in animal models for its targeting of adipose-tissue vasculature. Bolt Peptide does not offer Adipotide. It is discussed only as an experimental research compound and not for human use. Quick facts Class: targeted pro-apoptotic peptidomimetic (a homing peptide fused to a pro-apoptotic sequence). Molecular […]
GHRP-2 vs GHRP-6: What Is the Difference? (Research Overview)
Both GHRP-2 and GHRP-6 are synthetic growth-hormone-releasing peptides (GHRPs) that act as agonists at the ghrelin receptor (GHS-R1a). The key difference studied in the lab is that GHRP-6 is associated with stronger appetite-stimulating (ghrelin-like) signaling in animal models, while GHRP-2 is often characterized as a more potent growth-hormone (GH) secretagogue relative to its other effects. […]
What Is Thymalin? A Thymic Peptide Bioregulator Overview
Thymalin is a thymus-derived peptide preparation studied in immunological and peptide-bioregulator research. This article is an analytical overview of laboratory and published research models. Any referenced material is research-use-only and not for human or veterinary use. Quick facts Class: thymic peptide bioregulator (tissue-derived peptide complex) Source: originally isolated from calf (bovine) thymus tissue Research focus: […]
What Is LL-37? A Cathelicidin Antimicrobial Peptide Overview
LL-37 is the only human cathelicidin-derived antimicrobial peptide — a 37-amino-acid cationic, amphipathic peptide cleaved from the hCAP18 precursor protein. It is one of the most extensively studied host-defense peptides in laboratory research, where it is investigated for antimicrobial, immunomodulatory, and innate-immunity signaling activity. Research-use-only (RUO) note: LL-37 is referenced here strictly as a subject […]
What Is MGF (Mechano Growth Factor) and PEG-MGF?
MGF (Mechano Growth Factor) is a splice variant of insulin-like growth factor 1 — specifically the IGF-1Ec isoform — that is expressed in mechanically loaded or damaged muscle and is studied as a local tissue-repair factor in muscle-research models. PEG-MGF is a pegylated form of the peptide, engineered to improve stability and extend half-life for […]
What Is MK-677 (Ibutamoren)? A Research Overview
MK-677, also called ibutamoren, is a non-peptide research compound investigated as a growth-hormone secretagogue at the GHS-R1a (ghrelin) receptor. It has been studied in the scientific literature as a long-acting stimulator of the growth-hormone (GH) / insulin-like growth factor-1 (IGF-1) axis. Importantly, MK-677 is a synthetic small molecule — it is not a peptide, which […]
What Is SS-31 (Elamipretide / MTP-131)? A Research Guide
SS-31, also known as elamipretide or MTP-131, is a synthetic mitochondria-targeting tetrapeptide that binds cardiolipin on the inner mitochondrial membrane. It is studied in mitochondrial bioenergetics, oxidative-stress, and cellular-energy research. Any Bolt Peptide reference material is research-use-only and not for human or veterinary use. Quick facts Class: Szeto–Schiller (SS) mitochondria-targeted tetrapeptide Other names: elamipretide, MTP-131 […]
What Is Follistatin? A Myostatin-Pathway Research Overview
Follistatin is a naturally occurring secreted glycoprotein that binds and inhibits several members of the transforming growth factor beta (TGF-β) superfamily — most notably myostatin (GDF-8) and activin — and is studied as a negative regulator of these signaling pathways in muscle and tissue biology. Follistatin-344 (FS-344) is a commonly studied isoform/variant used in preclinical […]
